Activation of the EGFR, KRAS, and ALK oncogenes defines 3 various paths of molecular pathogenesis in lung adenocarcinoma. Nonetheless, many tumors lack activation of any path (triple-negative lung adenocarcinomas) posing a challenge for prognosis and therapy. Right Here, we report a comprehensive genome-wide phrase profiling of 226 main individual stage IвЂ“II lung adenocarcinomas that elucidates molecular traits of tumors that harbor ALK mutations or that absence EGFR, KRAS, and ALK mutations, that is, triple-negative adenocarcinomas. A hundred and seventy-four genes had been selected to be upregulated especially in 79 lung adenocarcinomas without EGFR and KRAS mutations. Unsupervised clustering utilizing a 174-gene signature, including ALK it self, classified these 2 categories of tumors into ALK-positive cases and 2 distinct categories of triple-negative cases (groups A and B). Particularly, team A triple-negative instances possessed a worse prognosis for relapse and death, in contrast to instances with EGFR, KRAS, or ALK mutations or group B triple-negative cases. A triple-negative cases, 9 genes were commonly overexpressed, including a candidate diagnostic/therapeutic target DEPDC1, that were determined to be critical for predicting a worse prognosis in ALK-positive tumors, 30 genes, including ALK and GRIN2A, were commonly overexpressed, whereas in group.